- Travelodge by Wyndham Orangeburg7.4Orangeburg
- Tru By Hilton Orangeburg8.5Orangeburg
- Holiday Inn Express & Suites Orangeburg by IHG8.2Orangeburg
- Baymont by Wyndham Orangeburg North5.5Orangeburg
- Comfort Inn & Suites Orangeburg7.3Orangeburg
- SureStay Hotel by Best Western Manning8.2Manning
- Quality Inn & Suites Orangeburg5.7Orangeburg
- Days Inn by Wyndham Orangeburg5.2Orangeburg
- Best Western PLUS Santee Inn8.6Santee
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